Why do we need stem cell in our skin?

As we age, our skin stem cell activity begins to slow down. These epidermal adult stem cells regenerate and rejuvenate the skin with fresh, healthy new cells, making skin youth and beautiful.



What is chromosome?


A chromosome is an organized structure of DNA and protein found in cells. It is a single piece of coiled DNA containing many genes, regulatory elements and other nucleotide sequences. Chromosomes also contain DNA-bound proteins, which serve to package the DNA and control its functions.


What is Telomeres?


Telomeres are repetitive DNA sequences located at the termini of linear chromosomes that protect the end of the chromosome from deterioration or from fusion with neighboring chromosomes. Telomere regions deter the degradation of genes near the ends of chromosomes by allowing chromosome ends to shorten, which necessarily occurs during chromosome replication. Over time, due to each cell division, the telomere ends do become shorter. If cells divided without telomeres, they would lose the ends of their chromosomes, and the necessary information they contain. 


What causes our skin to become old?


Our skin stem cells' regenerative ability should last a lifetime, but unhealthy lifestyle, stress and environmental factors such as pollution, UV rays hasten the depletion of skin cells, reduce their regenerative ability, and cause DNA damage and telomere shortening. This resulted in accelerated skin aging and skin problems such as listless skin, pigmentation, dehydrated, wrinkles, less elastic, irritated and easily damaged skin. 


What is HSP 27 & 70?


HSP is the acronym for Heat Shock Protein. HSP 27 & 70 is a family of ubiquitously expressed heat shock proteins exist in virtually all living organisms. Proteins with similar structure exist in virtually all living organisms. The main function of Hsp27 is to provide thermotolerance in vivo, cytoprotection, and support of cell survival under stress conditions. The Hsp70 are an important part of the cell's machinery for protein folding, and help to protect cells from thermal or oxidative stress.


Can I use other products after applying Juvenescence?


Yes, Juvenescence can be used intermittently along with your regular skincare regimen. 


Can I use Juvenescence on sensitive skin?


NEUZELL products contain NO Parabens, SLES, Alcohol, Mineral Oil, Artificial fragrances and artificial colors. However, it is recommended to test the product on small areas to determine individual sensitivity.


What does Telomere have to do with anti-ageing?

Telomere is part of our DNA strand where it is attached to the end of chromosome which acts like a bookend. Telomeres keep chromosome protected and prevent them from fusing into rings or binding with other DNA. Without telomeres, chromosome ends could fuse together and degrade the cell's genetic blueprint, making the cell malfunction, become cancerous or die.

When a cell divides and copies DNA, the strands of DNA get snipped to enable the copying process. The place that are snipped are the telomeres. The telomeres get shorter each time a cell divides, it allow cells to divide without losing genes. Cell division is needed so we can grow new skin, blood, bone and other cells when needed.

Most of the Researchers use the length of a cell's telomeres to determine the cell's age and how many more times it will replicate. this is important in anti-ageing research. Without telomeres, the ends of chromosomes would look like broken DNA, and the cell would try to fix something that wasn't broken. When cell stops replicating, it enters into a period of decline know a "cell senescence", which is the cellular equivalent of ageing.  


Where does Telomerase come from?

Every cell in your body has the genetic code to make telomerase, but only certain cells need to produce this enzyme. White blood cells and sperm cells, for example, need to have telomere shortening switched off in order to make more than 50 copies of themselves through your lifetime. In advanced cancer, the cancer cells also seem to be producing telomerase, which allows them to continue to replicate without dying.


Swiss Alps Botanical Stem Cell (PhytoCell)

What does Swiss Alps Botanical Stem Cell (PhytoCell) have to to with anti-ageing ?

Swiss Alps Botanical Stem Cell is a rare apples species named Uttwiler Spätlauber, it is found in canton Thurgau, northern Switzerland. It is rich in epigenetic factors and metabolites, its main functions include triggering the skin’s stem cell driven potential for infinite regeneration, stimulating its self renewing capacity of skin stem cells and insuring longevity of skin cells. It has won the Innovation Prize 2008 for Best Active Ingredient in Europe.

Storage ability of apples and skin aging

Apples have a very good storage abilities to stay fresh over months. This was an important factor for culvitar selection, modern apple cultivars are selected for intensive cultivation and for sweet flavour since storage is no longer a problem, Therefore cultivas with excelent storage abilities disappeared from the market.

Uttwiler Spätlauber

An old cultivar is still alive in Switzerland but no longer being cultivated, so the Spätlauber variety derives from a seeding planted in the middle of the 18th century and it was then cultivated in liquid systems in the lab, this tree was famous for its tremendous storability without shrinking as by today this is a very rare and endangered apple variety with only a few trees left in the world. The importance of the Uttwiler Spätlauber apple was honored by the release of a stamp in Germany.

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